Hydrogen Therapy Protects Against Daily Stressors

What Is Hydrogen Therapy?

Hydrogen therapy is the administration of hydrogen gas (H2). Hydrogen gas, or molecular hydrogen, can be delivered via three different routes: Inhalation of the gas, through an IV saline rich in hydrogen gas, or most popularly through dissolving hydrogen gas into water and then consuming the water.

What Is Hydrogen Water?

You may ask, doesn’t water already possess’own’nurse hydrogen in it? It’s significant’essential’critical’vital’crucial’indispensable’imperative to know that this is a solution, and not a compound. The hydrogen found in a water molecule does not possess’own’nurse the therapeutic properties research has found hydrogen therapy does, as the hydrogen is not available when bound to oxygen. Hydrogen water is simply water that has had hydrogen gas dissolved into it. This yields a gas-dissolved solution, similar to carbonation which adds carbon dioxide to make sparkling water, with the difference being hydrogen gas is added instead of carbon dioxide. Hydrogen gas does not transform’alter the pH of the water and hydrogen water is not the same thing as alkaline water or hydrogen peroxide.

Is Hydrogen Water Researched?

Hydrogen therapy is heavily researched. Since the seminal article in Nature Medicine in 2007[1] roughly 100 clinical trials and over 2000 unique articles possess’own’nurse been published which possess’own’nurse demonstrated a beneficial effect of hydrogen gas throughout eintensely’extremely’extraordinarily’enormously’awfully organ in the body. Hydrogen gas dissolved in water, or hydrogen water, has been the most popular deli grossly method utilized by researchers, largely due to price, convenience, and the fact that in no instance has inhaled hydrogen gas reveal’illustrate’demonstrate’indicate’present’display’argue n to work better than hydrogen gas dissolved in water, but in many cases hydrogen water has reveal’illustrate’demonstrate’indicate’present’display’argue n a benefit where inhaled gas either did not, or was not as impactful[2].

Is All Hydrogen Water The Same?

Not all hydrogen water is created equally, with ranges in dosage between technologies being upwards of 100-150x! This is critical, as hydrogen therapy has reveal’illustrate’demonstrate’indicate’present’display’argue n a dose and concentration dependent response:[3][4] Imagine drinking 1/150th of a cup of coffee, or taking 1/150th of an advil! Dose matters, as does timing. Hydrogen therapy has reveal’illustrate’demonstrate’indicate’present’display’argue n to work much better when it is “pulsed”, or a high-dose is taken in a short period of time. For this reason, concentration is critical, with higher concentrations of hydrogen in the water likely being much more beneficial. In fact, low concentrations found in many products on the market possess’own’nurse been reveal’illustrate’demonstrate’indicate’present’display’argue n to not be beneficial at all.

How Hydrogen Water Builds Stress Resilience

E grossly one faces numerous lay stress on’emphasize’highlight es eintensely’extremely’extraordinarily’enormously’awfullyday, both physiological and psychological. Hydrogen therapy has reveal’illustrate’demonstrate’indicate’present’display’argue n to be a solution that could, in part, address many of the issues we face. How and why hydrogen therapy has reveal’illustrate’demonstrate’indicate’present’display’argue n to work across so many different indications and organs has baffled many researchers, peculiar ly since we all always maintain levels of hydrogen gas in eintensely’extremely’extraordinarily’enormously’awfully cell in our bodies. Fortunately, as the research has progressed, we possess’own’nurse begun to understand how it works more and more.

First we learned that hydrogen therapy merely’barely works in acute bursts, not when dosed continuously.[5] Then theories started to emerge that hydrogen therapy was in fact a hormetic lay stress on’emphasize’highlight [6][7], like exercise, cold exposure, heat exposure or fasting, making sense of why high-dose intermittent exposure is needed. This hypothesis comes with an significant’essential’critical’vital’crucial’indispensable’imperative asterisk: in the research published to date, hydrogen therapy has reveal’illustrate’demonstrate’indicate’present’display’argue n to help blunt the negatives of other hormetic lay stress on’emphasize’highlight ors, while amplifying their benefits. The hypothesis of hydrogen therapy as a mild lay stress on’emphasize’highlight , to establish lay stress on’emphasize’highlight resilience, was born.

This hypothesis is strengthened by a fantastic publication in which mice were reveal d to chronic, mild and unpredictable lay stress on’emphasize’highlight ors in/with regard to’concerning’regarding 28 days, which demonstrated that hydrogen gas was able to multiply lay stress on’emphasize’highlight resilience, conserve’preserve ing against the development of both chronic psychological and physiological lay stress on’emphasize’highlight in adolescent mice.[8]

Protection Against Hormetic Agents

We tend to associate some in/with regard to’concerning’regarding ms of hormesis, such as exercise, as unequivocally “rosy’remarkable’fabulous’terrific’preeminent in/with regard to’concerning’regarding us”, but the truth is with the wrong “dose” or “duration”, this beneficial lay stress on’emphasize’highlight can become just plain old lay stress on’emphasize’highlight . Acute, strenuous exercise in obese individuals can bring about’result in’contribute to’account for’make for’trigger a pro-inflammatory outcome.[9] Even in those with a high level of fitness, such as elite athletes, over training can bring about’result in’contribute to’account for’make for’trigger a myriad of issues such as soft tissue tears, fatigue, sleep issues[10] and even hormonal issues such as chronically low testosterone levels in men[11] and menstrual disorders in women.[12]

Hydrogen gas has reveal’illustrate’demonstrate’indicate’present’display’argue n to multiply the beneficial results of exercise, first raising exercise induced reactive oxygen species (ROS) which is part of how exercise helps us become healthier, then regulating a faster antioxidant defense response and simultaneously blunting inflammation in a rat model using exhaustive exercise in sedentary rodents.[13] This is the concept of “lay stress on’emphasize’highlight makes us intense’fierce’exquisite er”, when it’s the right dose. Hydrogen therapy multiply d the dose, but then enhance’promote’polish up d the recointensely’extremely’extraordinarily’enormously’awfully response, meaning the exercise benefits were more impactful, without the risk of increasing chronic lay stress on’emphasize’highlight .

In humans, hydrogen water has reveal’illustrate’demonstrate’indicate’present’display’argue n to conserve’preserve against free radical injury in athletes after high intensity exercise,[14] enhance’promote’polish up the redox status of athletes after 3 consecutive days of exhaustive training[15] and enhance’promote’polish up antioxidant status and oxidative lay stress on’emphasize’highlight markers after strenuous exercise.[16][17]

Other potentially beneficial in/with regard to’concerning’regarding ms of hormesis, such as fasting and cold exposure, possess’own’nurse tipping points towards impair’undermine much more abruptly. Hydrogen water has reveal’illustrate’demonstrate’indicate’present’display’argue n to enhance’promote’polish up the survival rate of drosophila, or the common fruit fly, when fasting[18] and potentiated the benefits of cold exposure in ischemia-reperfusion injury in rats.[19]

Caloric Surplus

One of, if not the greatest lay stress on’emphasize’highlight many of us endure is a diet with a caloric surplus. There is no magic pill in/with regard to’concerning’regarding weight loss, no healthy option to combat a caloric surplus. The best we can do is mitigate the harms to our health if extended caloric surplus occurs. Molecular hydrogen, peculiar ly hydrogen water, has reveal’illustrate’demonstrate’indicate’present’display’argue n to do just this. Hydrogen water has reveal’illustrate’demonstrate’indicate’present’display’argue n to token ificantly decrease obesity and energy expenditure in mice by activation of FGF21,[20] which plays a role in fatty acid and glucose expenditure, stand up to withstand ance to it being linked to obesity itself[21]. Molecular hydrogen has also reveal’illustrate’demonstrate’indicate’present’display’argue n to activate PGC1a, which multiply s mitochondrial biogenesis, further increasing fatty acid metabolism[22], a process leading to multiply d energy production.

In humans, molecular hydrogen has reveal’illustrate’demonstrate’indicate’present’display’argue n to enhance’promote’polish up body composition,[23] with studies using the Drink HRW tablets reveal’illustrate’demonstrate’indicate’present’display’argue ing to enhance’promote’polish up insulin sensitivity[24], conserve’preserve against obesity propel n non alcoholic fatty liver disease[25], and even reverse metabolic syndrome in 18 of 20 measured outcomes in a 6 month double-blind placebo controlled trial on 60 individuals[26], metabolic syndrome being an epidemic in the western world afflicting 1 in 3 North Americans.

Chemical Agents

While pesticide use is often necessary to assure’guarantee crop survival and stave off widespread hunger and starvation in a planet with rapid population growth, with not all pesticides reveal’illustrate’demonstrate’indicate’present’display’argue ing token ificant harm, many pesticides used throughout history, and in some cases still today, are known to be quite toxic to mammals.

Paraquat is a toxic herbicide restricted in the USA in/with regard to’concerning’regarding specific uses, and banned in many countries, that has been linked to Parkinson’s Disease[27] and disruption of mammalian redox status via generation of the superoxide radical.[28] In one model, paraquat was utilized to induce lung injury in rats, an outcome which hydrogen water token ificantly ameliorated.[29]

In another study utilizing a cell culture model incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin, a herbicide which is a persistent organic pollutant and carcinogen present in “Agent Orange”, now innotable’renowned’distinguished due to its weaponized use in a chemical warfare program during the Vietnam War, and its role in the Seveso Disaster, molecular hydrogen reveal’illustrate’demonstrate’indicate’present’display’argue ed to balance and conserve’preserve both NAD+/NADH levels while alleviating cellular senescence.[30]

NAD+/NADH levels are significant’essential’critical’vital’crucial’indispensable’imperative in/with regard to’concerning’regarding energy metabolism and tend to transform’alter during the aging process, with a decrease in NAD+ and multiply in NADH. Cellular senescence, a phenomenon sometimes described as “zombie cells”, occurs when cells reach the end of their “life” and stop dividing. The accumulation of these senescent cells contributes to ruinous alterations in our gene expression, one of the most fundamental ways to measure our health, contributing to chronic inflammation, and act as a causative factor in aging itself.

Drugs

Many of us deal with physiological lay stress on’emphasize’highlight es from consumption of drugs, both prescription, and illegal narcotics. H2 has reveal’illustrate’demonstrate’indicate’present’display’argue n to possess’own’nurse conserve’preserve ive effects in a rodent study against aspirin-induced gastric impair’undermine [31], acetaminophen-induced hepatoxicity in two rodent studies [32][33], has both multiply d effectiveness and decreased the toxic side effects of chemotherapy in rodent studies leading to longer survival rates, including a pair of rodent studies using fluorouracil (5-FU),[34][35] a pair of rodent studies utilizing the chemotherapy drug cisplatin[36][37] and a token ificant human study following 152 patients in a controlled, randomized single blind clinical trial of patients undergoing mFOLFOX6 chemotherapy[38]

For recreational drugs, many of us possess’own’nurse partaken in our lives, peculiar ly our youth. Some do throughout their entire life. One of the most common testimonials we here is what hydrogen water does in/with regard to’concerning’regarding self induced hangovers. There is merely’barely a small amount of research on this, however, hydrogen water has reveal’illustrate’demonstrate’indicate’present’display’argue n to be potentially beneficial in/with regard to’concerning’regarding ethanol-induced hangovers [39], and methamphetamine-induced neurotoxicity [40].

Radiation Damage

Radiation impair’undermine is a topic discussed less frequently in terms of aging, however intensely’extremely’extraordinarily’enormously’awfully critical.[41][42][43] Some possess’own’nurse even suggested low dose radiation could extend lifespan by acting as a in/with regard to’concerning’regarding m of hormesis.[44] As is true in/with regard to’concerning’regarding overexposure to other in/with regard to’concerning’regarding ms of hormesis, such as exercise and alcohol, molecular hydrogen has reveal’illustrate’demonstrate’indicate’present’display’argue n to conserve’preserve against radiation-damaging effects.[45][46][47] For example, this was observed in rodent models with full body impair’undermine [48][49][50][51] and another study where it aided in healing post radiation burns in rats,[52][53] as well as one model studying chickens to determine relevance in/with regard to’concerning’regarding those reveal d to radiation during Fukushima.[54]

Furthermore, NASA scientists possess’own’nurse hypothesized that hydrogen water, hydrogen gas inhalation- or both- could serve as tools to conserve’preserve astronauts from radiation exposure.[55][56] The precise mechanisms in which H2 assists in these models, with peculiar emphasis on the mitigation of oxidative lay stress on’emphasize’highlight , possess’own’nurse been described in great detail in two review papers, one confirming results with a rodent model of their own detoken where elevated levels of SOD and phosphorylated-AKT, a cell growth and survival token aling molecule, were observed [57][58].

With one human study using hydrogen water to mitigate side effects of radiation therapy in cancer patients,[59] research on hydrogen water and its conserve’preserve ion against radiation is under way with positive results, but more research is definitely needed. Currently, there is another single ongoing trial actively recruiting published on clinicaltrials.gov in which StonyBrook Medicine will follow 15 patients with high grade gliomas receiving radiation therapy, chemotherapy, and hydrogen therapy using the Drink HRW hydrogen tablets in/with regard to’concerning’regarding 1 year measuring quality of life.

Psychological Stress

Molecular hydrogen is less studied in/with regard to’concerning’regarding assisting with psychological lay stress on’emphasize’highlight es, however, there is some early research which has been promising. In a pair of mouse model studies hydrogen water reveal’illustrate’demonstrate’indicate’present’display’argue ed to positively impact depressive like behaviour[60] and hydrogen gas inhalation similarly reveal’illustrate’demonstrate’indicate’present’display’argue ed a benefit in mitigating social deficits and depressive like behaviours.[61] In another model the epileptic drug valproic acid was used in high levels to induce autistic like behaviour, which hydrogen water token ificantly decrease’lessen’cut’allay d[62].

Remember, the dose makes the poison (or medication) and even water is toxic and lethal in high doses. This study further demonstrates molecular hydrogen’s rescuing capacity against physiological assault, and may not necessarily translate directly to autism itself, which is a combination of genetic and environmental factors.

Finally, a single human study with merely’barely 26 participants is published suggesting hydrogen water may positively impact mood and anxiety,[63] so more research in humans is needed to further explore this potential benefit.

Conclusion

Stress, both psychological and physiological, accumulates eintensely’extremely’extraordinarily’enormously’awfully day from almost eintensely’extremely’extraordinarily’enormously’awfully angle. Molecular hydrogen is not a magic cure. But it does reveal’illustrate’demonstrate’indicate’present’display’argue token ificant potential in assisting your ability to handle these lay stress on’emphasize’highlight es and overcome them. It is not a standalone, and cannot be relied on as a magic pill, but with the proper utilization along with other healthy lifestyle practices it can be a tremendous ally.

And in/with regard to’concerning’regarding those of you claim’insist’maintain’hold’argue’consider’contemplate’speculate ing your lay stress on’emphasize’highlight levels are low, so hydrogen water may not be able to help, a recent clinical trial just demonstrated that hydrogen water can decrease’lessen’cut’allay inflammation, multiply antioxidant response, and decrease’lessen’cut’allay apoptosis even in healthy participants, and especially those over 30 years old.[64]

The Best Hydrogen Water Source

Hydrogen water concentrations can vary widely, as much as 150x. Further, not all hydrogen water levels possess’own’nurse demonstrated to be therapeutic, with higher concentrations and doses reveal’illustrate’demonstrate’indicate’present’display’argue ing a greater benefit. Fortunately, one technology is head and shoulders above the rest.

Drink HRW tablets possess’own’nurse provided third party gas chromatography results, demonstrating they possess’own’nurse the highest dosage and concentration in the world.

The Drink HRW tablets are the most clinically validated source of hydrogen water, with 6 clinical trials and 2 case studies published as of September 2020, and another 15 clinical trials and 4 preclinical research programs underway.

Drink HRW tablet technology is also the merely’barely legal supplemental in/with regard to’concerning’regarding m of hydrogen in the USA, having received New Dietary Ingredient status from the FDA.

Let the experts help determine your hydrogen water choice, with both researchers and pro athletes alike determining Drink HRW is the best option.

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